Johnston Press, the owner of the Yorkshire Post and Yorkshire Evening Post, is selling the offices that have been home to the dailies for the past 42 years.
The landmark Wellington Street building, and the Wakefield Express office in Southgate, will be put on the market the publisher said.
“Key editorial staff” in Wakefield will move to a central office in the town. All other staff will move to new offices at the Number 1 Leeds development on Whitehall Road in Leeds.
The move is expected to take place from early October.
Helen Oldham, managing director of Yorkshire Post Newspapers, said: “I am delighted that we have secured new high profile, quality, city centre premises for our Leeds and Wakefield businesses.
“The move signifies a sizeable investment in our people and will provide an environment in which we can take our highly regarded media brands forward positively.”